Amy Bloom tells the story of her husband, Brian, getting Alzheimer's and wanting assisted suicide. Her search to find a way to do that led her to Dignitas, in Switzerland.

Host Ira Glass interviews author Alain de Botton about why so many of us choose the wrong spouses. Botton is the author of the new novel The Course of Love.

We have an update on a man in his 70s who planned to propose to a woman. We first spoke with him for time in our episode The Heart Wants What the Heart Wants.

Ira talks to a man in his 70s who’s about to travel across the country to tell a woman he loves how he really feels, despite some very real signs that doing so might be a bad idea.

Host Ira Glass speaks with musician Kristy Kruger about the unique way she dealt with a recent breakup.

Ira talks with Jessica Pressler, who writes the Daily Intel blog for NewYork Magazine, about a phenomenon she noticed in the wedding notices in The New York Times. Couples were cheerfully telling—as part of their "meet cute" stories—how their relationships began with one of them cheating on a spouse or long-time partner.

Joel and Kate were both working in a psychiatric hospital in Belmont, Massachusetts. They both like each other, and she tries to impress him by always wearing her favorite pair of jeans.

We meet Russell, 19, the best mobile phone salesman in the mall — and possibly anywhere. His talent for sales is matched only by those of his girlfriend, Chandler, 18, a waitress.

Musician David Berkeley has gotten a lot of requests in his life, but none quite like the offer his agent got last year. A fan wanted Berkeley to come to his house and help save his relationship by serenading the troubled couple with a personal concert.

Host Ira Glass talks with Lauren Waterman, who's in the middle of a break-up right now and grappling with totally contradictory feelings. (5 minutes)

Host Ira Glass talks to Chicago Tribune newspaper columnist Amy Dickinson ("Ask Amy"), the heir to Ann Landers, as she reads letters from those readers who don't yet know their love is doomed.

Host Ira Glass talks to film critic Jonathan Rosenbaum of the Chicago Reader about an anonymous love letter that turned out to be very different than it seemed.

Host Ira Glass talks with Michael Beaumier, who runs the personals section of the Chicago Reader, and who functions as a kind of guardian angel for many of the singles who advertise in his paper.

Host Ira Glass explains how you can get away with anything if you claim you did it for love.

We hear a tape that a man named David Cossin made for a woman in Italy named Allesandra whom he'd met during a week he spent there, and with whom he'd fallen in love. He sent her a dozen tapes, including one where he tries to convince her to move to New York and be with him.

A high school student explains the intricacies of a four-year crush, and declares that having a crush can be better than having a boyfriend.

When Adam and Jamie were kids, Jamie would always ask for Adam's advice, but he didn't want to hear what Adam would say himself. Instead, he wanted Adam to pretend to be an Israeli commando he once knew, named Yakov.

Scott Richer and Julie Riggs of Louisville, Kentucky, were supposed to have their first kiss at the corner where South Fourth Street meets the alley behind the West End Baptist Church. But it went wrong.

When Anne Staggs started to fall for an inmate named Charles in the Texas prison system, she was up against odds as daunting as they ever get for two people. It was against the rules, possibly dangerous, and could have gotten her fired.

Viola disguises herself as a man, takes a job working for this guy with whom she promptly falls in love. He believes the pretense: He thinks Viola is a man, so he never gives her a second look.

Ira talks with Maria, who took out a personals ad in the Chicago Reader advertising herself as "wacky and warm." (5 minutes)

In the early stages of the Monica Lewinsky scandal, there was a period when one of the questions raised by the whole affair had to do with monogamy. Around that time, Roy Romer, the Governor of Colorado and Chair of the Democratic Party, admitted that for 16 years he'd had a relationship with an aide that his wife and family knew about.