Producer Alex Blumberg explains that he wanted to do this show because of his conflicted relationship with his own testosterone. He tells host Ira Glass that the reasons go back to a girl in his eighth-grade homeroom and the 1970s seminal feminist novel The Women's Room. We also hear from a man who stopped producing testosterone due to a medical treatment and found that his entire personality was altered.

Host Ira Glass goes to a fake wedding at a home for Alzheimer's patients in Davenport, Iowa. Two high school kids who've never even kissed are the bride and groom.

Host Ira Glass explains that when you name names, when you whistleblow, when you tell on someone, you often do it anonymously. We hear from one anonymous squealer, who was done wrong by her doctor—he messed up a procedure and then refused to fix it.