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Act One: Mother Of Invention

Karen Sosnoski's one-year-old son, Anton, was born with what's known as Mosaic Down Syndrome, a rare condition where some of his cells have the extra chromosome that causes Down syndrome and other cells don't. So as he grows, he could end up having all the health risks and challenges of Down syndrome...or just a few of them.

Prologue

Host Ira Glass introduces a story on the most ambitious and hopeful solution to urban poverty in the country—the Harlem Children's Zone. The project's goal is nothing less than changing the lives of thousands of children in Harlem, starting at birth and continuing until they go to college.

Act One: Harlem Renaissance

Paul Tough reports on the Harlem Children's Zone, and its CEO and president, Geoffrey Canada. Among the project's many facets is Baby College, an 8-week program where young parents and parents-to-be learn how to help their children get the education they need to be successful.

Prologue

Amy Roberts thought it was obvious that she was an adult, not a kid, and she assumed the friendly man working at the children's museum knew it too. Unfortunately, the man had Amy pegged all wrong.

Act Three: Educated Guess

When Amy Silverman's daughter was born with Down syndrome, she followed the advice of all the parents she met: She signed her daughter up for "early intervention" therapy. But her daughter's progress had unexpected consequences, forcing Amy to make a choice she'd never predicted.

Prologue

Host Ira Glass talks with Kayla Hernandez, a seventh-grader who likes to reminisce about when she was a child, back in fifth grade. She visits Room 211 in her school, where her fifth grade class met, and looks at her old books, thinks about what happened there.

Act Four: When We Were Angels

The most innocent possible student uprising imaginable...documented by an actual student, Hillary Frank, using the crude tools of a telephone answering machine and a shiny red boom box.

Act One: Rubber Room

We hear from New York City school teachers about a secret room in the New York City Board of Education building. Teachers are told to report there, and when they arrive, they find out they're under investigation for something.

Act Two: Bar Car Prophesy

Writer Rosie Schaap tells the story of how she ingratiated herself into the adult society of the Metroliner commuter train bar car as a teenager. She would cast Tarot card prophesies for riders, in exchange for beer.

Act Four: Tough News Room

Malcolm Gladwell is a best-selling author and famous journalist at the New Yorker magazine. But not always.