David Sedaris, author of Me Talk Pretty One Day, explains how the most important moments of your life can happen in a car...and you can miss them.

Kelly Keggers demonstrates how there are angels on the road in San Francisco.

An '88 Grand Marquis that Senator Conrad Burns inherited from his mother; a New York taxicab whose driver, Jeff Perkins, tape-records his passengers to help pass the time; a 1980s-era BMW 5 series in which film producer Rob Levine had his first job as driver and assistant to movie producer Edgar Sherrick.

Nick Hornby, author of High Fidelity and About a Boy, explains the travails of driving his autistic son to the park.

Host Ira Glass explains the premise of the show, and we hear what's actually going on inside five of these cars.