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Act One: Mother Of Invention

Karen Sosnoski's one-year-old son, Anton, was born with what's known as Mosaic Down Syndrome, a rare condition where some of his cells have the extra chromosome that causes Down syndrome and other cells don't. So as he grows, he could end up having all the health risks and challenges of Down syndrome...or just a few of them.

Prologue

Host Ira Glass introduces a story on the most ambitious and hopeful solution to urban poverty in the country—the Harlem Children's Zone. The project's goal is nothing less than changing the lives of thousands of children in Harlem, starting at birth and continuing until they go to college.

Act One: Harlem Renaissance

Paul Tough reports on the Harlem Children's Zone, and its CEO and president, Geoffrey Canada. Among the project's many facets is Baby College, an 8-week program where young parents and parents-to-be learn how to help their children get the education they need to be successful.