Producer Nancy Updike tells the story of scientists who simply made up an invisible, weightless subatomic particle called the neutrino. Then they set out on the task of finding it, using tools that sound positively crude: A mineshaft and 100,000 gallons of dry cleaning fluid.

Before this show ended we wanted to know—how typical are the horror stories? What happens in a typical drug case? To find out, reporter Nancy Updike spent nine hours in Night Narcotics Court in Chicago. What she discovers is that the system is working as fairly as one could hope or expect, with one caveat: Nearly all the defendants are African-American, even though the jurisdiction contains an equal number of white drug users.

When adults talk babytalk to each other, it is precisely to avoid having real conversations and experiencing real moments with each other. People almost never discuss babytalk in public. This American Life producer Nancy Updike and her boyfriend—Chicago journalist Adam Davidson—agreed to step forward and speak the truth on the subject.

Unlike Reykjavik, some cities don't coddle citizens in their idiosyncratic beliefs about nature. We hear New York mayor Rudolph Giuliani react (with vehemence) to a man who believes New Yorkers should have the right to keep ferrets in their homes.

A few years back Alex Kotlowitz wrote a book called There Are No Children Here, about two boys growing up in Chicago's Henry Horner public housing projects. Those projects were across the street from the site of the 1996 Democratic Convention in Chicago, and when the convention came to town, money poured in for a makeover.

How fundamentalist Christians and Orthodox Jews are combining forces to breed a perfect red cow that could bring about the end of the world. Ira talks with cattleman and minister Clyde Lott, and with New Yorker writer Lawrence Wright.

What happens when you go into a place—in this case a prison—where there are all sorts of codes about what you're never supposed to say...and you say every one of them. Rick Reynolds tells a story from his one-man show (and CD) All Grown Up and No Place to Go, about performing stand-up comedy at a maximum security prison just before Christmas a few years ago.

Journalist Steve Bogira tells the story of Vincent Bogan, who said "no" to something once—a decade ago, when he was 21—and now has to live with that one decisive act. Bogan was arrested and charged with 17 counts of armed robbery.

Writer/performer Danny Hoch performs a monologue taken from his one man show, Jails, Hospitals and Hip-Hop. It's a story about a guy who's been locked up for doing the most American activity possible: Selling stuff on the street (in this case Bart Simpson/O.J. Simpson t-shirts).

Yet another testimony to the power chickens have over our hearts and minds. Jack Hitt reports on an opera about Chicken Little.

Host Ira Glass with Rory Evans, who describes the day her father fired his own mother from their family business, a machine shop called Evans Industries.

A reading of a pamphlet written by ex-con Stephen Donaldson for heterosexual men who are about to enter prison, about how to "hook up" with a stronger man —"daddy" or "jocker"—who'll provide protection in return for sex. He explains the rules and mores that govern this part of American prison culture.

Twenty-six-year-old Jose William Huezo Soriano—a.k.a. Weasel—grew up in Los Angeles.

This American Life host Ira Glass and producer Susan Burton spent a week in August recording a suburban Chicago youth group at every stage of their very first mission trip. The teenagers were from Covenant Presbyterian Church in Chicago.

When Anne Staggs started to fall for an inmate named Charles in the Texas prison system, she was up against odds as daunting as they ever get for two people. It was against the rules, possibly dangerous, and could have gotten her fired.

Host Ira Glass with former Congressman Daniel Rostenkowski. When Rostenkowski began a term in federal prison, he met for the first time people who'd been locked up under harsh drug laws that he'd voted for himself. "The whole thing's a sham," he declares.

Barbara Clinkscales grew up in Chicago's public housing projects, had her first child when she was 15, and is now—over two decades later—struggling to get her teenage son to finish his senior year of high school. Barbara is a working mom, with a network of close friends who look out for her.

When Brigid starting going blind, she tried to hire someone to drive her around. Only problem was, the guy she hired wanted to carry her groceries, hold her arm as she walked to the curb...he tried to help her in too many ways.

Host Ira Glass with an idealistic would-be politician in California. The puzzle of American politics is that our political system is filled with idealistic people, but few of our candidates for top office seem either idealistic or capable of inspiring passion.

Writer Mike Paterniti tells a story of dogs and a community of dogwalkers that formed on the grounds of an old cemetery at the corner of Vaughn and Clifford in Portland, Maine.

There's the pretending we do as individuals, and there's the organized pretending that happens in group therapy sessions, in the roleplaying games that are done in some clinical settings. Jack Hitt tells the story of the Mother of All Roleplaying Games.

Professor Glenn Loury from Boston University and John Simpkins on basketball, hockey, and what makes a real black person.