Host Ira Glass plays tape of two women who ended up as frenemies.They kept trying to be friends, but couldn't help themselves from fighting. Ira then speaks with psychologist Julianne Holt-Lunstad who has run scientific studies to answer the question: Why don't we simply end these troubling kinds of friendships? Holt-Lunstad's research also shows that these relationships are much more common than you might think.

Ira talks with Jessica Pressler, who writes the Daily Intel blog for NewYork Magazine, about a phenomenon she noticed in the wedding notices in The New York Times. Couples were cheerfully telling—as part of their "meet cute" stories—how their relationships began with one of them cheating on a spouse or long-time partner.

Ira talks with lexicographer Erin McKean about the origin of the word frenemy.

Mike Birbiglia explains the chain of events that resulted in him becoming the fall guy for his entire high school, and how it took him a while to catch on to what was happening. This story was recorded live in front of an audience in Cambridge, Mass.

This American Life producer Sarah Koenig reports on a very surprising reason why insurance companies dump members, and how this reasoning contradicts President Obama's argument for what will lower health care costs.

Host Ira Glass talks with Susan Dentzer, editor of the journal Health Affairs, about what current health reform proposals do to fix the rising costs of healthcare...And points at a surprising, kind of heartening phenomenon happening within the current debate.

Mike Birbiglia recalls being in a car accident with a hit and run drunk driver. In the weeks that follow, Mike's brush with death turns into a full blown nightmare when the police report is so poorly filled out that somehow Mike winds up owing the drunk driver 12 thousand dollars…not because it's fair, but because he can't get anyone to listen to him.

Host Ira Glass visits This American Life producer Sarah Koenig at her house in State College PA, a few blocks from Penn State's campus, on a weekend night near one in the morning. They witness all kinds of alcohol-induced mayhem.

Planet Money reporter Chana Joffe-Walt asks a simple question: Who was the federal regulator who was supposed to be regulating AIG? The answer turns out to be far from simple.

Not everyone hates the idea of "toxic assets." Reporter Lisa Chow goes to New Jersey to follow two guys on their quest to clean up some of America's bad mortgages—by buying them, and going straight to the homes themselves to have a look at how dire the situation really is.

Host Ira Glass talks to business professor Pino Audia and Fast Company magazine columnist Dan Heath about corporate creation myths, and why so many of them involve garages.

Host Ira Glass describes a recent terrorism case in Newburgh, N.Y., in which four men were arrested after planting bombs in front of a synagogue and Jewish community center. Ira discusses the case with Aziz Huq, assistant professor at the University of Chicago Law School and co-author of Unchecked and Unbalanced: Presidential Power in a Time of Terror. Huq says the Newburgh case isn't what it seems, because without the help of a government informant, the four men probably wouldn't have been able to organize an act of terrorism.

Anna Boiko Weyrauch talks with a woman in the West African country of Ghana about the internet dating scams she has pulled on white Americans. The woman says she felt guilty about the scams and eventually came clean to her marks.

This American Life Senior Producer Julie Snyder talks to Ira about her rather alarming theory regarding the new president's smoking habits.

Host Ira Glass talks with NPR correspondent Adam Davidson about a black tie event he attended in the spring of 2008. The event was an awards dinner for finance professionals who created the mortgage-based financial instruments that nearly brought down the global economic system.

Host Ira Glass talks to Rich Farrell, writer and former addict, about the code of silence he learned as a kid, and the times he took the fall for his friends' misdeeds.

Ira talks with reporter My Thuan Tran of The Los Angeles Times about how San Jose City Councilwoman Madison Nguyen went from being the "golden child" of the Vietnamese community to someone who faced weekly protests and a hunger striker. Turns out red-baiting is alive and well in the Vietnamese-American community.

Barack Obama's transition team made it clear this week that the incoming president plans to order the closing of the Guantanamo Bay detention camp on his first full day in office. It's also likely that he'll immediately suspend the military commissions held there—the special courts the military set up in Guantanamo that have been widely criticized as unfair to the detainees. This American Life Producer Sarah Koenig talked to one of the military lawyers currently defending a Guantanamo detainee about all this—what's going on there, and what should happen next.

More stories of travelers and workers at a highway rest stop. The competition between Plattekill and Maine continues.

Administrators have tried everything to curb drinking at Penn State, and nothing has worked. Producer Sarah Koenig reports on why this issue is so hard to tackle, and on how students react when a student dies from alcohol poisoning.

Alex Blumberg and Adam Davidson tackle a very tough subject: Trying to explain exactly what a bank is and does. They talk to a number of experts about what has gone wrong in banking, but not before bringing us all up to speed on some banking basics, like understanding a bank balance sheet, and a bank's assets and liabilities, and the squishy business of what banks say about their balance sheets compared to what they are.Alex and Adam walk us step by step through the complications of the US government buying up bad assets from banks, and explain why, when it comes to footing the bill, the government might just prefer to not be in charge of the very banks it is having taxpayers bailout.

Adam Davidson and Chana Joffe-Walt from Planet Money head to the Hunts Point Market in the Bronx, a bustling area of vegetable and fruit commerce that only comes alive at night. Planet Money is a co-production of NPR News and This American Life.

Dan Savage points a finger at the Catholic Church for being the kind of criminal organization that drives him to atheism—despite the fact that he still wants to believe he'll see his mom in heaven someday. Dan writes the sex advice column Savage Love and is the author of several books including The Commitment.