Reporter Susan Burton tells the story of a high-speed chase in South Dakota. An incident at a high school basketball game escalated to the point where a group of Native American girls from one town found themselves being chased down the highway by a group of white boys from another town.

The story of what happens to an average American family, when a perfectly normal, rational and funny mom starts spending every day in the company of an ancient Buddhist monk named Aaron, who no one else can see. Davy Rothbart is one of her three sons, and also the reporter for this story.

The classifieds are populated by people in flux. People selling stuff from old lives in transition new ones.

An interview with a transgender man, who started life as female and began taking testosterone injections several years ago. He explains how testosterone changed his views on nature vs. nurture for good.

Nancy Updike reports that life under curfew in Ramallah can be, among other things, intensely boring. She also tells the story of Sam Bahour, a Palestinian who was born and raised in Ohio, who came back to the West Bank in 1995, when peace seemed possible, to help build the Palestinian state.

A fable of how America got its name, and how it was named after someone who was a fraud, but the kind of fraud people love, the kind of fraud who knows how to please a crowd. Jack Hitt tells the racy and little-known story of how Amerigo Vespucci got his name all over the map of the western hemisphere by telling lies about what he found there—the type of lies which can be found today in the pages of Penthouse magazine.

Jon Ronson tells the story of how his parents decided to commission a family portrait, and how things went awry because of the brilliant but troubled local artist they hired for the job. In the story, Jon circles in a reluctant orbit around his parents, and his parents are in a rather energetic orbit of their own.

We hear from a mother and her son. By age seven, he'd had heart failure and been diagnosed as bipolar.

Ira talks with Barry Keenan, who was living a lot of people’s plan A in the early 60’s. He was rich, he was successful.

Starlee Kine tells the story of a man more obsessed with reruns than even she is. Director Trent Harris made a movie called The Beaver Trilogy.

In 1973, the American Psychiatric Association (APA) declared that homosexuality was not a disease simply by changing the 81-word definition of sexual deviance in its own reference manual. It was a change that attracted a lot of attention at the time, but the story of what led up to that change is one that we hear today, from reporter Alix Spiegel.

You can't do a program about middlemen without a story about business. In this act, we hear from a man who made his living buying low and selling high...incredibly high, sometimes at mark-ups of up to 1,000 percent.

In any family, giving other people what they want becomes fantastically complicated, often because people tend to give others the things they'd like themselves. Curtis Sittenfeld explains how the drama plays out in her family, when it comes to her father's weight.

The story of a man who committed a murder when he was a teenager. He got away with it, and didn't tell the police for twenty years.

This American Life senior producer Julie Snyder explains the office politics of street vendors on the corner of Sixth Avenue and Eighth Street in New York City. With her is sociologist Mitch Duneier, who spent years working with the vendors and writing about them for his book Sidewalk.