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Prologue

Producer Alex Blumberg explains that he wanted to do this show because of his conflicted relationship with his own testosterone. He tells host Ira Glass that the reasons go back to a girl in his eighth-grade homeroom and the 1970s seminal feminist novel The Women's Room. We also hear from a man who stopped producing testosterone due to a medical treatment and found that his entire personality was altered.

Act Four: The Cinema Of Upward Mobility

Home movies usually don't have much of a plot—one of the many ways they differ from Hollywood movies. But reporter Susan Burton has a lifetime of home movies, which together describe a very Hollywood plot, about how she remade herself from a friendless nerd into a popular girl.

Act Three: Mr. Fun

Jonathan Goldstein and Heather O'Neill tell the true story of what happens when a person tries to intrude on a idyllic family of two, one of whom loves him, one of whom does not. For the first few years Jonathan knew Heather, her daughter Arizona was not very fond of him.

Act Two

Alix Spiegel's story continues, with a man dressed in a Nixon mask called Dr. Anonymous, and a pivotal encounter in a Hawaiian bar.

Prologue

Ira summarizes the results of an informal poll of about a hundred people, about whether they were living their Plan A or Plan B and recounts a moment from a short story by author Ron Carlson. (2 minutes)Ron Carlson's story is called "Plan B for the Middle Class," it's from his book by the same name. 

Act Two: Special Effects Story

Kevin Murphy is a college student in Idaho who stutters. Using the power of radio editing, he and the production staff of This American Life removed his pauses, stutters and repeats so that he could record a message the way it seems the rest of the world would like to hear him sound.

Act Two: Snitch

The story of how common and perfectly legal police interrogation procedures, procedures without violence or torture, were able to get an average fourteen-year-old suburban kid to confess to murdering his own sister...even though DNA evidence later proved that he hadn't done the crime.

Act Two

Brent Runyon tells the story of the day in eighth grade that he set himself on fire...and what led to that. He wasn't a loner, he had friends, his mother was a teacher, his parents took an interest in his life.

Act One: The Big Night

Jonathan Goldstein made every girl he ever dated watch the home movie of his family's Rosh Hashanah dinner he made when he was 17. He hoped that seeing his family life on film might make the women more sympathetic to his shortcomings.