Will Seymour reads letters he and his grandmother exchanged when he was in high school. He was miserable at the time—his parents had just gotten divorced and he had no friends—and so was his grandma.

This American Life producer Sarah Koenig tells the story of how her stepsister Rue bought a house on the cheap, with the understanding that the previous owner would soon move out. More than ten years later, she's still waiting.

Host Ira Glass interviews the mother and daughter in a family who wished for years they could do something to stop their neighbor from all kinds of shocking behavior. Suddenly they get the power to decisively change things forever...and they have to decide whether they will.

Karen Sosnoski's one-year-old son, Anton, was born with what's known as Mosaic Down Syndrome, a rare condition where some of his cells have the extra chromosome that causes Down syndrome and other cells don't. So as he grows, he could end up having all the health risks and challenges of Downs syndrome...or just a few of them. Through a website, Karen found a kid with the same diagnosis, named Tim Colvin, who was doing really well...perhaps because his mother, Kristy, invented a surprising and unusual way to raise her son.

In this show, at the Museum of Contemporary Art, Ira and David Hauptschein explored this now utterly quaint question: Are people having experiences on the Internet they wouldn't have anywhere else? Several hundred listeners sent in samples of what they were finding on the Internet. A guy offers a girl a late-night tour of Microsoft...and this actually makes him seem hot.