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Prologue

Story of a romance that began in a mental hospital. Sometimes, the line between crazy and not crazy is blurry; certain behavior could mean either thing.

Act Two: Guinea Pig Zero

Ira interviews Bob Helms, creator of the zine Guinea Pig Zero, which is about people who make their living by donating their bodies to science for medical experiments. Bob says he wouldn't do spinal tap studies or psychoactive drugs (he calls the people who do the latter "brain sluts").

Prologue

Host Ira Glass, with a recording of a 1962 Frank Sinatra, Dean Martin, and Sammy Davis Jr., appearance at the Villa Venice, a club outside Chicago. What's fascinating about Sinatra is how he is so many different people at once, and they're all on display in this recording: sentimental crooner, cruel woman-baiter, bully, goofball.