Karen Sosnoski's one-year-old son, Anton, was born with what's known as Mosaic Down Syndrome, a rare condition where some of his cells have the extra chromosome that causes Down syndrome and other cells don't. So as he grows, he could end up having all the health risks and challenges of Down syndrome...or just a few of them.

Host Ira Glass introduces a story on the most ambitious and hopeful solution to urban poverty in the country—the Harlem Children's Zone. The project's goal is nothing less than changing the lives of thousands of children in Harlem, starting at birth and continuing until they go to college.

Elna Baker reads her story about the time she worked at the giant toy store, FAO Schwartz. Her job was to sell these lifelike "newborns" which were displayed in a "nursery" inside the store.

When Sarah was 10 years old, she got a heart transplant. Soon after, her mother decided to find out more about the person who saved her daughter's life.

Host Ira Glass asks fifth-grade kids to explain what adults do wrong when talking to children.

Eight-year-old Betsy Walter goes on a campaign to understand her parents' divorce.

This American Life regular contributor Davy Rothbart talks about the time a friend asked him to make a decision for her that she really had to make for herself: Whether she should have an abortion. Davy is the founder and publisher of Found Magazine and author of a book of short stories, The Lone Surfer of Montana, Kansas.

Psychologist Harry Harlow sets out to prove, through a series of experiments with monkeys, that love is a key to normal development in children.

Karen Sosnoski's one-year-old son, Anton, was born with what's known as Mosaic Down Syndrome, a rare condition where some of his cells have the extra chromosome that causes Down syndrome and other cells don't. So as he grows, he could end up having all the health risks and challenges of Downs syndrome...or just a few of them. Through a website, Karen found a kid with the same diagnosis, named Tim Colvin, who was doing really well...perhaps because his mother, Kristy, invented a surprising and unusual way to raise her son.

Producer Jane Feltes talks with the first people on line for the bus to Colorado: Two twin, six-year-old sisters.

Nick Hornby's new story about a country so tiny, it's just a field, a few houses, a shop, and a café. There, a boy whose mom happens to be president of this minuscule nation is called upon to show his patriotism by playing on the national soccer team.

Julie Hill explains how she's going to remake all the ideas her son has about his father, using a very simple tactic.

Six-year-old DJ has two dads, Dan Savage and Terry Miller. DJ is being raised by two gay men, but he has a preschooler's understanding of what gay means.

Scott Carrier and his family live in the same Salt Lake City neighborhood as Elizabeth Smart, the fourteen-year-old whose kidnapping made international news in 2002. Though pictures of Smart were everywhere in Salt Lake City, and thousands of volunteers searched for her, her captors brought her back to the neighborhood she was taken from, and they walked freely through the streets with her.

Shalom Auslander reads his true story, "The Blessing Bee." It's about the time when, as a third-grader at an Orthodox Jewish school, Shalom saw his chance to both make his mom proud, and push his drunken father out of the picture. Part of his scheme involved winning the school's bee on the complicated Hebrew blessings you say before eating certain foods.

Writer Beth Lisick decides to try a new strategy to get her infant to sleep better, and buys a baby monitor as part of the deal. Soon, she's hearing her neighbors make drug deals over the monitor's frequency.

Washington Irving Elementary School became a model of school reform in Chicago a decade ago. The school did it without adding a ton more money.

When she was three years old, Georgia was caught by immigration officials when a Milwaukee woman tried to bring her into the country illegally from Jamaica. She ended up at a residential detention center in Chicago.

Host Ira Glass talks with two sisters, one high-school age, the other younger, about who gets treated better in the family. They all agree the youngest does.

It's hard to give things up. Host Ira Glass tells the story of Walter, a three-year-old boy who had to give up his pacifier, and then, wanting comfort, asked all the adults around him to tell the stories of when they gave up their pacifiers.