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Act One: Mother Of Invention

Karen Sosnoski's one-year-old son, Anton, was born with what's known as Mosaic Down Syndrome, a rare condition where some of his cells have the extra chromosome that causes Down syndrome and other cells don't. So as he grows, he could end up having all the health risks and challenges of Down syndrome...or just a few of them.

Prologue

Host Ira Glass introduces a story on the most ambitious and hopeful solution to urban poverty in the country—the Harlem Children's Zone. The project's goal is nothing less than changing the lives of thousands of children in Harlem, starting at birth and continuing until they go to college.

Act One: Harlem Renaissance

Paul Tough reports on the Harlem Children's Zone, and its CEO and president, Geoffrey Canada. Among the project's many facets is Baby College, an 8-week program where young parents and parents-to-be learn how to help their children get the education they need to be successful.

Act One: I'm The Decider

This American Life regular contributor Davy Rothbart talks about the time a friend asked him to make a decision for her that she really had to make for herself: Whether she should have an abortion. Davy is the founder and publisher of Found Magazine and author of a book of short stories, The Lone Surfer of Montana, Kansas.

Act One: Mother Of Invention

Karen Sosnoski's one-year-old son, Anton, was born with what's known as Mosaic Down Syndrome, a rare condition where some of his cells have the extra chromosome that causes Down syndrome and other cells don't. So as he grows, he could end up having all the health risks and challenges of Downs syndrome...or just a few of them. Through a website, Karen found a kid with the same diagnosis, named Tim Colvin, who was doing really well...perhaps because his mother, Kristy, invented a surprising and unusual way to raise her son.

Act Three: Invisible Girl

Scott Carrier and his family live in the same Salt Lake City neighborhood as Elizabeth Smart, the fourteen-year-old whose kidnapping made international news in 2002. Though pictures of Smart were everywhere in Salt Lake City, and thousands of volunteers searched for her, her captors brought her back to the neighborhood she was taken from, and they walked freely through the streets with her.

Act Three: Oedipus Hex

Shalom Auslander reads his true story, "The Blessing Bee." It's about the time when, as a third-grader at an Orthodox Jewish school, Shalom saw his chance to both make his mom proud, and push his drunken father out of the picture. Part of his scheme involved winning the school's bee on the complicated Hebrew blessings you say before eating certain foods.

Act Two: Exodus Of One

When she was three years old, Georgia was caught by immigration officials when a Milwaukee woman tried to bring her into the country illegally from Jamaica. She ended up at a residential detention center in Chicago.

Prologue

It's hard to give things up. Host Ira Glass tells the story of Walter, a three-year-old boy who had to give up his pacifier, and then, wanting comfort, asked all the adults around him to tell the stories of when they gave up their pacifiers.