Alix Spiegel's story continues, with a man dressed in a Nixon mask called Dr. Anonymous, and a pivotal encounter in a Hawaiian bar.

An act named after two TV shows, one where women sit around and talk, the other where men sit around and talk. If men are from Mars and women are from Venus, when you switch from one planet to another, what do you need to know about love? We hear from several transsexual men who've done exactly that.

Regular This American Life contributor Dan Savage, a syndicated sex columnist with possibly the filthiest mouth of anyone you could ever meet, finds a TV program so dirty, so weird, and so perverted that he won't let his son watch it—even though it's a kids' show, made for kids, and broadcast on a network for kids.

Seattle writer and syndicated sex columnist Dan Savage, on how there's a stigma against sissies even among gay men. Gay personals ads are filled with men who want "straight acting/straight appearing" partners.

Host Ira Glass talks with his mom—a clinical psychologist—about why people seem to rarely take the advice others give. Then advice columnist Dan Savage, author of the syndicated column and book Savage Love, gives the audience some advice that hopefully might save lives.

From the ages of 12 to 27, our producer Elna Baker was supposed to confess to male clergy anytime she did anything sexual. It was so routine for her that she barely thought to talk about it.

When Susan Bergman wrote a book about her family's experience, other gay men tried to explain her father's actions to her.

Ira Glass mentions a very silly mistake he made with a girl when he was in junior high. Then comedian Mike Birbiglia tells the story of his rocky foray into the world of making out with girls.

From England, Ruby Wright has a story of an affair where—even years after it ended—it wasn't much discussed. Ruby Wright's radio show Ruby's Chicky Boil-Ups airs every other Sunday on Radionowhere.

When the United States Congress saw a problem — sex trafficking — it acted to eliminate it.

Kurt Braunohler and his girlfriend had been together for thirteen years, and they were only 30. They wondered why they had never considered marriage, and realized that they needed to sleep with other people before they tied the knot.

Producer Jonathan Menjivar tells the story of John Smid, a gay man who did not want to be gay, and who tried to get other gay people to suppress their urges as well. Then...John changed.

David Sedaris tells a story about how, as a teenager, he was scared of certain people...until he made them scared of him, one fateful night. Sedaris is the author of Me Talk Pretty One Day and other books.

Susan Bergman's father was a family man, head of the church choir, and, secretly, having sex with men. He died before his children had a chance to really talk to him about what they should make of his hidden life.

Writer and nationally syndicated sex columnist Dan Savage explains what actually happens in non-monogamous couples, how they make it work, and whether they're happy.

Ira calls up his mother Shirley Glass after unexpectedly finding her quoted as a “sexpert” in Marie Claire magazine, back in 1996. One of the first stories we did on our show.

In 1973, the American Psychiatric Association (APA) declared that homosexuality was not a disease simply by changing the 81-word definition of sexual deviance in its own reference manual. It was a change that attracted a lot of attention at the time, but the story of what led up to that change is one that we hear today, from reporter Alix Spiegel.

Sketches from the neo-futurists on the subject of double lives.

Two-and-a-half years after Jack Hitt wrote the story that makes up Act One of our show, he returned to the tale of Dawn Langley Simmons.

Over the last ten years in Los Angeles, there's been a noticeable increase in the number of transsexual teenagers, kids who were born as boys but live as girls, and vice versa. Cris Beam has spent the last two years getting to know these kids, and tells the story of two of them, Foxxjazell and Ariel.

A reading of a pamphlet written by ex-con Stephen Donaldson for heterosexual men who are about to enter prison, about how to "hook up" with a stronger man —"daddy" or "jocker"—who'll provide protection in return for sex. He explains the rules and mores that govern this part of American prison culture.

Found zoophilia letters read.

Six-year-old DJ has two dads, Dan Savage and Terry Miller. DJ is being raised by two gay men, but he has a preschooler's understanding of what gay means.

Ira talks with Jessica Pressler, who writes the Daily Intel blog for NewYork Magazine, about a phenomenon she noticed in the wedding notices in The New York Times. Couples were cheerfully telling—as part of their "meet cute" stories—how their relationships began with one of them cheating on a spouse or long-time partner.