Ira invites Buffy the Vampire Slayer creator Joss Whedon to perform a song from his Dr. Horrible's Sing-Along Blog DVD extra commentary, which is a musical satire that pokes fun at the idea of DVD commentary.

Host Ira Glass talks with his mom—a clinical psychologist—about why people seem to rarely take the advice others give. Then advice columnist Dan Savage, author of the syndicated column and book Savage Love, gives the audience some advice that hopefully might save lives.

Ira Glass mentions a very silly mistake he made with a girl when he was in junior high. Then comedian Mike Birbiglia tells the story of his rocky foray into the world of making out with girls.

David Sedaris wishes he could take back a wish. He's the author of Me Talk Pretty One Day and other books.

When a pet dies, to what degree can it be replaced by another? And to what degree can pets replace people in our lives? David Sedaris tells this story of cats and dogs and other animals.

A live performance detailing a humiliating love affair. When comedian Mike Birbiglia was in high school, he fell for a cool girl named Amanda.

Jeff Simmermon tells a story from his days as a student teacher, about a time when he decided to forgo all the rules, and administer frontier justice on the fly. This story was recorded in front of an audience at the Moth storytelling series.

David Rakoff discusses the world of birthdays and other holidays, as they're celebrated on the job... and what happens when you call yourself an editorial assistant but the editor you're assisting calls you a secretary. He read this story before a live audience at Town Hall in New York City, during a This American Life live show.

When a pet dies, to what degree can it be replaced by another? And to what degree can pets replace people in our lives? David Sedaris tells this story of cats and dogs and other animals.

A fable about gossip and the service industry involving a cat and a baboon, by David Sedaris. David's story was recorded live at UCLA's Royce Hall, as part of UCLA's Performing Arts series.

David Sedaris tells a story about how, as a teenager, he was scared of certain people...until he made them scared of him, one fateful night. Sedaris is the author of Me Talk Pretty One Day and other books.

Sarah Vowell tells the lost story behind a patriotic song, "The Battle Hymn of the Republic." An early version of the song celebrated an American terrorist. She's accompanied by Jon Langford and the band.

Will Seymour reads letters he and his grandmother exchanged when he was in high school. He was miserable at the time—his parents had just gotten divorced and he had no friends—and so was his grandma.

Joshuah Bearman tells a story that’s a sequel to his memorable episode about his mother and half-brother David. It’s done onstage as a play that’s structured like a radio documentary, with Josh Hamilton playing Joshuah, and James Ransone playing his brother.

Why is it that karaoke machines only have songs on them? If what they do is take a version of a public performance and allow the rest of us to give our own interpretations of the material, why aren't there other options, like the "you talkin to me?" scene from Taxi Driver, or Martin Luther King, Jr.'s "I Have a Dream" speech. Jonathan Goldstein and producer Starlee Kine find out why when they go to a karaoke club that has, along with all the songs, comedy routines for people to perform.

David Sedaris has this instructive tale of how, as a boy, with the help of his dad, he tried to bridge the chasm that divides the popular kid from the unpopular — with the sorts of results that perhaps you might anticipate.

What if you asked people for advice and actually took all the advice that everyone gave you? As an experiment, writer Sarah Vowell tried exactly that, when she recently solicited advice from many different people about insomnia.

In the second half of the show, she talks about her own cancer — cervical cancer that was diagnosed six months after her brother got sick. Julia eventually turned some of these vignettes into a one-woman show called God Said, Ha!, which Quentin Tarantino made into a movie and Julia released as a book.

There's a town in Florida where if you shoplift, and get caught, a judge will send you back to the scene of your crime to stand in front of the store, with a large sign that reads "I stole from this store." Ira and producer Lisa Pollak talk to one such teenager who was caught stealing from a convenience store, the supervisor overseeing her punishment, and the judge who sends her there.

Mike Birbiglia talks about the sleepwalking that nearly killed him. (13 minutes)This story is an excerpt of Mike's one-man show, "Sleepwalk with Me," which also became feature film, produced and co-written by Ira Glass.

Julia talks about her brother Michael's cancer. He was diagnosed with non-Hodgkins lymphoma, stage four.

David Sedaris outlines an experiment he conducted with fluids and a tube and a bag. The result: The Stadium Pal.

Comedian Sasheer Zamata stages a radio play, complete with sound effects and comedians Nicole Byer, Chris Gethard, and Frank Garcia Hejl. It’s a true story about a recent bus accident.

Ira tells the story of Lucia Lopez, a former gang member who would beat you up if she caught you looking at her...and how her life changed when she put herself in a position where hundreds of people were looking at her.